Charting the Kingdoms Between

Conversations between kingdoms: small RNAs.

Humans, animals, and plants are constantly under attack from pathogens and pests, resulting in severe consequences on global human health and crop production. Small RNA (sRNA)-mediated RNA interference (RNAi) is a conserved regulatory mechanism that is involved in almost all eukaryotic cellular processes, including host immunity and pathogen virulence. Recent evidence supports the significant c...

NSTAR12: Charting the interaction between light quarks

Two of the basic motivations for an upgraded JLab facility are the needs: to determine the essential nature of light-quark confinement and dynamical chiral symmetry breaking (DCSB); and to understand nucleon structure and spectroscopy in terms of QCD’s elementary degrees of freedom. In addressing these questions one is confronted with the challenge of elucidating the role of quarks and gluons i...

Another Bridge between Kingdoms: tRNA Splicing in Archaea and Eukaryotes

in a multistep process requiring ATP and GTP, leaving a 2Ј-phosphate at the splice junction. In a remarkable * Molecular Genetics Program Wadsworth Center final step, the phosphotransferase removes the 2Ј phosphate by transfer to NAD, generating a mature tRNA New York State Department of Health and School of Public Health with a standard 3Ј–5Ј linkage at the ligation junction Archaeal tRNA intr...

Charting the Interplay between Structure and Dynamics in Complex Networks

Alzheimer's disease: charting the crossroads between neurology and psychology.

Neurodegenerative disorders such as Alzheimer's disease (AD) are increasingly recognised to have a long prodromal stage before the onset of symptoms defining the dementia syndrome. This phase may last up to years or even decades. An intensive search has been initiated for signs or symptoms that might enable prediction of dementia development.1 The motivation for identifying such predictors come...